class switching meaning

• [Medicine]
  Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

• When the B cells get activated, class switching can occur.
• Class switching occurs by a mechanism called class switch recombination ( CSR ) binding.
• In B lymphocytes ( B cells ), interferon gamma stimulates antibody class switching.
• On the other hand, immunoglobulin class switching causes heavy chain rearrangement of the mature B cell ..
• In addition, cytokines are factors that have great effects on class switching of different classes of antibodies.
• Class switching occurs in the heavy chain gene locus by a mechanism called class switch recombination ( CSR ).
• Their interaction with B cells provides the appropriates signals needed for B cells differentiation and eventual class switching occurrence.
• IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production.
• One of the main physiological changes that occurs during an adaptive immune response is a process called immunoglobulin class switching.
• The class switching involves switch regions that made up of multiple copies of short repeatts ( GAGCT and TGGGG ).

• "class switching" meaning in Chinese: (类别转换)：在淋巴细胞分化过程中免疫球蛋白质重链c 区表达的转换。
• "class switching" meaning in Japanese: クラススイッチ